Efficacy of astragalin on lead acetate induced nephrotoxicity in male albino rats

Abstract :

The nephroprotective efficasy of astragalin (kaempferol-3-O-glucoside) isolated from flowers of pongamia pinnata against lead acetate induced nephrotoxicity was studied in male albino rats. Administration of 160 mg/kg body weight/day of lead acetate for 90 days to male albino rats, resulted in significant elevation in the level of serum urea, creatinine and uric acid and decreaced levels of kidney superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), reduced glutathione (GSH), vitamin C and vitamin E also in the kidney of treated rats when compared to control. Astragalin at a dose of 20 mg/kg/b.w when combinely administrerd with 160mmg/kg/b.w of lead acetate, significantly brought the levels of serum urea, uric acid, creatinine and activities of SOD, CAT, GPx, GR, GST, GSH, vitamin C and vitamin E in the kidney comparably similar to that of untreated (control) rats. The present results indicated that astragalin treatment might protect the kidney tissues against free radical - mediated oxidative stress induced by lead acetate.