Evaluation of Antioxidant activity of Jackfruit Leaves (Artocarpusheterophyllus, Lam.)

Abstract :

Oxidative stress has been recognized as a key driver of many ailments affecting humankind. Plants have been used for many ages across time to manage human diseases and have a host of antioxidant phytocompounds. Artocarpus hetero phyllusis traditionally used for the management of inflammation, malaria fever, rheumatism, and insanity, among other diseases caused by a disturbed redox state in the body. In this study, in vitro antioxidant activities of the methanolic leaf extracts of Artocarpus heterophyllus were evaluated. The in vitro antilipid peroxidation, the 1,1-diphenyl-2-picryhydrazyl (DPPH) free radical scavenging, and the ferric reducing antioxidant power assay methods. The obtained results revealed remarkable antioxidant activities of the studied plant extracts as evidenced by the low IC50 and EC50 values. These antioxidant activities could be due to the presence of antioxidant phytochemicals like flavonoids, carotenoids, tannins, and phenols, among others. Therefore, the therapeutic potency of this plant could be due to its antioxidant properties. This study recommends in vivo antioxidant efficacy testing of the studied plant extracts, as well as isolation and characterization of bioactive antioxidant compounds that are potent against oxidative stress.