Synergetic actions of some commonly used phyto-chemicals augment cell cycle arrest actions in Cancer cells: A Review
Arresting the growth of the cells during the cell cycle is one of the main targets in cancer therapy. There are varied therapeutic chemicals to target the cancer cell growth available both in current as well as in alternative medicines from
plant sources. Of the many plant polyphenols that have been studied and found to play a role in the cell cycle arrest, the most commonly used polyphenols from Turmeric (curcumin), Green Tea (EGCG) and ginger (6-gingerol) are studied extensively. All these three are reported to control cancer cell’s proliferation by arresting the growth at different phases of the cell growth cycle. As they are targeting a common factor, the cell growth, by following a different or a similar molecular paths, it is expected that, their efficacy is likely to improve due to possible synergistic action when they are used together. Research findings that support this hypothesis are analyzed.
Keywords: Plant polyphenols, cancer, cell cycle arrest, synergism.
Citation: *, ( 2018), Synergetic actions of some commonly used phyto-chemicals augment cell cycle arrest actions in Cancer cells: A Review. Scientific Transactions in Environment and Technovation Journal(STET), 12(2): 106-111
Received: 11/14/2017; Accepted: 12/13/2018;