In Vitro Antidiabetic potential of Aegle marmelos

R. Kalaiselvi¹ *,

Diabetes Mellitus is a systemic metabolic disease characterized by hyperglycemia, abnormal elevated levels of lipid, and fat in blood and hypoinsulinaemia. This study aims at determining the anidiabetic potential of five traditional medicinal plants such as, Aegle marmelos. The selected plant leaves were subjected to solvent extraction and analyzed for their antidiabetic activity using in vitro assays such as, á-amylase inhibition assay, glucose difusion assay, glucose uptake by yeast cells, and nonenzymatic glycosylation assay. The extract of Aegle marmelos was used at the concentration
range of 7.5, 15.5, 31.2, 62.5, 125, 250, 500,and 1000 ug/ml and standard acarbose. The results of the assays suggest that among the selected plants, ethanol extract of the Aegle marmelos was significant in inhibiting the activity of á-amylase with IC50 value of 1000μg/ml. Further assays proved that the same was efficient in its antidiabetic potential. The phytochemical analysis showed the presence of phenols, flavonoids and alkaloids as major amount. Thus the study suggests that Aegle marmelos could be considered as a potential source of natural antidiabetic agents.