Influence of mineral supplementation on the growth performance of Madars
Red lambs under different systems of management

Abstract :

The reaction between t(3)-methyl-r(2),c(6)-diphenylpiperidin-4-one and Propane-1,2-diol yielded a diastereomeric product of 2,6-dimethyl-7,9-diphenyl-1,4-dioxa-8-azaspiro[4.5]decane. The structure of the newly synthesized compound was analysed by using spectroscopic methods such as IR, one-dimensional NMR (1H and 13C) and two-dimensional NMR (NOESY). The spectral data revealed that the compound adopt chair conformation with equatorial orientation of all the substituents. The newly synthesized compound was tested for their antifungal activity against Penicillium notatum, Candida albicans, Mucor sp, Aspergillus nige and, Fusarium solani using micro dilution method. The compound 2,6-dimethyl-7,9-diphenyl1,4-dioxa-8-azaspiro[4.5] decane displayed inhibitory activity with MIC value of 15.625 µg ml-1 in controlling the growth of M. indicus, A.niger and, F. solani and 31.25 µg ml-1 for P.notatum C. albicans.