Isolation and identification of flavonoid from mycorrhizal and non
mycorrhizal roots and rhizomes of Acorus calamus

Abstract :

In vivo anti nephrotoxic activities of the whole plants of Abutilon indicum and Boerhaavia diffusa, their formulation and individual extracts were determined in in vivo models against nephrotoxicity in rats, induced with gentamicin. A control group (water, group I, n = 6) was compared with rats administrated 40 mg/kg gentamicin, once daily for 21 days (Groups II, III, IV, V and VI). The effect of ethanolic extract of Abutilon indicum and Boerhaavia diffusa formulation and individual extract (Groups IV,V and IV) at a dose level of 200 mg/kg was compared in gentamicin-induced nephrotoxicity. The activities of urea, uric acid, creatinine, sodium and potassium were significantly increased in rats exposed to gentamicin. Administration of ethanolic extract of formulation prevented severe alterations of biochemical parameters. In conclusion, this study obviously demonstrated that pretreatment with ethanolic extract of formulation significantly attenuated the physiological alterations induced by gentamicin. Also, the present study identifies new areas of research for development of better therapeutic agents for kidney diseases.