Hepatoprotective activity of Phyllanthus emblica Linn. extract against paracetamol-induced hepatic damage in rats.

Abstract :

The efficacy of the medicinal plant Phyllanthus emblica Linn. to prevent paracetamol-induced hepatotoxicity in rats was examined by determining the concentrations of biochemical markers of liver enzymes Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alkaline Phosphatase (ALP) and Acid Phosphatase(ACP), and triglycerides, protein, cholesterol and phospholipids in serum. Treatment with aqueous extract of fruits of Phyllanthus emblica Linn. improved the levels of biochemical molecules to near normal levels suggesting the hepatoprotective effect of this medicinal plant.